Effect of a monoclonal anti-carcinoembryonic antigen antibody-ricin A-chain conjugate on human carcinoembryonic antigen-producing tumor cells.
نویسندگان
چکیده
منابع مشابه
Human immune response to anti-carcinoembryonic antigen murine monoclonal antibodies.
We previously demonstrated that patients with carcinoembryonic antigen [CEA]-producing neoplastic tumors, treated with murine monoclonal antibody to CEA, produced antibodies directed against the constant regions [human anti-mouse antibody (HAMA)] and the idiotypes [anti-Id] of these murine immunoglobulins. In this study, we describe a method for analyzing the presence of such antibodies in the ...
متن کاملHuman Immune Response to Anti-Carcinoembryonic Antigen Murine Monoclonal Antibodies1
We previously demonstrated that patients with carcinoembryonic an tigen |CKA|-producing neoplastic tumors, treated with murine monoclonal antibody to CEA, produced antibodies directed against the constant regions [human anti-mouse antibody (HAMA)| and the idiotypes (antiId) of these murine immunoglobulins. In this study, we describe a method for analyzing the presence of such antibodies in the ...
متن کاملSerum Levels of Carcinoembryonic Antigen and a Tumor-extracted Carcinoembryonic Antigen-related Antigen in Cancer Patients1
Levels of Carcinoembryonic antigen (CEA) and a tumor-ex tracted CEA-related antigen (TEX) were determined in sera from patients with carcinomas of the breast, colon, lung, head and neck, and a number of miscellaneous categories. The purpose of this study was to compare the levels of each antigen at various stages of malignant disease. Competitive radioimmunoassays developed in our laboratory we...
متن کاملSerum levels of carcinoembryonic antigen and a tumor-extracted carcinoembryonic antigen-related antigen in cancer patients.
Levels of carcinoembryonic antigen (CEA) and a tumor-extracted CEA-related antigen (TEX) were determined in sera from patients with carcinomas of the breast, colon, lung, head and neck, and a number of miscellaneous categories. The purpose of this study was to compare the levels of each antigen at various stages of malignant disease. Competitive radioimmunoassays developed in our laboratory wer...
متن کاملTumor, red marrow, and organ dosimetry for 131I-labeled anti-carcinoembryonic antigen monoclonal antibody.
Tumor-, red marrow-, and organ-absorbed doses were calculated for patients receiving 131I-labeled monoclonal antibodies against carcinoembryonic antigen for either diagnosis or therapy. Ten patients with confirmed liver tumors who received doses ranging from 10.79 to 200 mCi were evaluated. Urine and blood samples were taken in order to determine total body and red marrow activity, respectively...
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ژورنال
عنوان ژورنال: Journal of Pharmacobio-Dynamics
سال: 1984
ISSN: 0386-846X,1881-1353
DOI: 10.1248/bpb1978.7.593